MolNFT v1 · #67610 · protein
Human transthyretin (ttr) complexed with a palindromic bivalent amyloid inhibitor (7 carbon linker).
3IPE: “Human transthyretin (ttr) complexed with a palindromic bivalent amyloid inhibitor (7 carbon linker).”. X-ray diffraction, 1 ligand (JZE). MolNFT v1 #67610 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3IPE
- Type
- protein
- Length
- 230 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transthyretin
- UniProt
- P02766
- Ligands
- JZE
Structure
x-ray diffraction · 1 distinct chain · 6% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Transthyretin | protein | 115 | 6% helix, 53% strand | P02766 |
Ligands and binding sites
- JZE · 2,2'-{heptane-1,7-diylbis[oxy(3,5-dichlorobenzene-4,1-diyl)imino]}dibenzoic acid · ligand · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 947 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 3IPE · Human Transthyretin (TTR) complexed with a palindromic bivalent amyloid inhibitor (7… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02766
- Elsewhere: RCSB PDB 3IPE · PDBe 3IPE · UniProt P02766
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