MolNFT v1 · #6751 · protein
Molybdopterin synthase (MOAD/MOAE)
1FMA · Molybdopterin converting factor, subunit 1: “Molybdopterin synthase (MOAD/MOAE)”. X-ray diffraction, 1 ligand (CL), 3 pockets (best druggability 0.41). MolNFT v1 #6751 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1FMA
- Type
- protein
- Length
- 223 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Molybdopterin converting factor, subunit 1; Molybdopterin converting factor, subunit 2
- UniProt
- P30748, P30749
- Ligands
- CL
- Pockets
- 3 · best druggability 0.41
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D | Molybdopterin converting factor, subunit 1 | protein | 81 | 27% helix, 27% strand | P30748 |
| E | Molybdopterin converting factor, subunit 2 | protein | 142 | 37% helix, 37% strand | P30749 |
Ligands and binding sites
- CL · Chloride ion · ion · 3 copies · chains D, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 114 | 0.41 | 0.76 | 23 | CL |
| 2 | 75 | 0.35 | 0.76 | 18 | empty |
| 3 | 68 | 0.31 | 0.74 | 13 | empty |
Interfaces
1 interface between chains.
- D–E · 941 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 isopeptide (isopeptide).
Compared structures
- 1FMA · Molybdopterin synthase (MOAD/MOAE) · the same entry in another collection · chain D against D, TM-score 1.00
- P30749 · AlphaFold monomer V2.0 prediction for molybdopterin synthase catalytic subunit (P30749) · a predicted model of the same protein · chain E against A, TM-score 0.97
- P30748 · AlphaFold monomer V2.0 prediction for molybdopterin synthase sulfur carrier subunit… · a predicted model of the same protein · chain D against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30748
- Every structure of UniProt P30749
- Elsewhere: RCSB PDB 1FMA · PDBe 1FMA · UniProt P30748 · UniProt P30749
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