MolNFT v1 · #67490 · protein

Apo crystal structure of protein tyrosine phosphatase from entamoeba histolytica featuring a disordered active site

3ILY · Protein tyrosine phosphatase, putative: “Apo crystal structure of protein tyrosine phosphatase from entamoeba histolytica featuring a disordered…”. X-ray diffraction, 4 pockets (best druggability 0.60). MolNFT v1 #67490 on…

PDB: 3ILY
Type: protein
Length: 281 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein tyrosine phosphatase, putative
UniProt: C4LSE7
Pockets: 4 · best druggability 0.60

Structure

x-ray diffraction · 2 distinct chains · 51% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein tyrosine phosphatase, putative	protein	142	51% helix, 12% strand	C4LSE7
B	Protein tyrosine phosphatase, putative	protein	139	51% helix, 12% strand	C4LSE7

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	291	0.60	0.78	38	empty
2	77	0.51	0.84	15	empty
3	130	0.47	0.78	19	empty
4	94	0.35	0.75	23	empty

Interfaces

1 interface between chains.

A–B · 572 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

3ILY · Apo crystal structure of protein tyrosine phosphatase from Entamoeba histolytica… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt C4LSE7
Elsewhere: RCSB PDB 3ILY · PDBe 3ILY · UniProt C4LSE7

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