MolNFT v1 · #67328 · protein
Crystal structure analysis of mglu in its native form
3IH8 · Salt-tolerant glutaminase: “Crystal structure analysis of mglu in its native form”. X-ray diffraction, 8 pockets (best druggability 0.61). MolNFT v1 #67328 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3IH8
- Type
- protein
- Length
- 826 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Salt-tolerant glutaminase
- EC
- 3.5.1.2
- UniProt
- Q4U1A6
- Pockets
- 8 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Salt-tolerant glutaminase (EC 3.5.1.2) | protein | 415 | 47% helix, 17% strand | Q4U1A6 |
| B | Salt-tolerant glutaminase (EC 3.5.1.2) | protein | 411 | 45% helix, 16% strand | Q4U1A6 |
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 420 | 0.61 | 0.76 | 42 | empty |
| 2 | 329 | 0.59 | 0.77 | 33 | empty |
| 3 | 237 | 0.46 | 0.73 | 37 | empty |
| 4 | 206 | 0.45 | 0.74 | 31 | empty |
| 5 | 58 | 0.41 | 0.81 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 718 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 3IH8 · Crystal Structure Analysis of Mglu in its native form · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q4U1A6
- Elsewhere: RCSB PDB 3IH8 · PDBe 3IH8 · UniProt Q4U1A6
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