MolNFT v1 · #6727 · protein

Molecular basis for CD40 signaling mediated by TRAF3

1FLK · TNF receptor associated factor 3: “Molecular basis for CD40 signaling mediated by TRAF3”. X-ray diffraction, 2 pockets (best druggability 0.32). MolNFT v1 #6727 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1FLK
Type: protein
Length: 410 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TNF receptor associated factor 3
UniProt: Q13114
Pockets: 2 · best druggability 0.32

Structure

x-ray diffraction · 1 distinct chain · 26% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	TNF receptor associated factor 3	protein	205	26% helix, 23% strand	Q13114

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	64	0.32	0.76	17	empty
2	50	0.25	0.73	13	empty

Compared structures

1FLK · Molecular basis for CD40 signaling mediated by TRAF3 · the same entry in another collection · chain A against A, TM-score 1.00
Q13114 · AlphaFold monomer V2.0 prediction for TNF receptor-associated factor 3 (Q13114) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13114
Elsewhere: RCSB PDB 1FLK · PDBe 1FLK · UniProt Q13114

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