MolNFT v1 · #67252 · protein

Crystal structure of the functional nanoarchaeum equitans tRNA splicing endonuclease

3IEY · TRNA-splicing endonuclease: “Crystal structure of the functional nanoarchaeum equitans tRNA splicing endonuclease”. X-ray diffraction, 1 pocket (best druggability 0.45). MolNFT v1 #67252 on GenesisL1: 3D structure, binding sites and…

PDB: 3IEY
Type: protein
Length: 299 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TRNA-splicing endonuclease; NEQ261
EC: 3.1.27.9
UniProt: Q74MP4, Q74MS9
Pockets: 1 · best druggability 0.45

Structure

x-ray diffraction · 2 distinct chains · 35% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	TRNA-splicing endonuclease (EC 3.1.27.9)	protein	147	33% helix, 29% strand	Q74MP4
B	NEQ261	protein	152	38% helix, 26% strand	Q74MS9

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	163	0.45	0.75	22	empty

Interfaces

1 interface between chains.

A–B · 1538 Å² buried · 27 hydrogen bonds · protein-protein

Compared structures

3IEY · Crystal Structure of the functional Nanoarchaeum equitans tRNA splicing endonuclease · the same entry in another collection · chain A against A, TM-score 1.00
Q74MP4 · AlphaFold monomer V2.0 prediction for tRNA-splicing endonuclease (Q74MP4) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q74MP4
Every structure of UniProt Q74MS9
Elsewhere: RCSB PDB 3IEY · PDBe 3IEY · UniProt Q74MP4 · UniProt Q74MS9

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