MolNFT v1 · #66946 · protein

NUP170(AA1253-1502) at 2.2 a, S.CEREVISIAE

3I5Q · Nucleoporin NUP170: “NUP170(AA1253-1502) at 2.2 a, S.CEREVISIAE”. X-ray diffraction, 3 pockets (best druggability 0.56). MolNFT v1 #66946 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3I5Q
Type: protein
Length: 496 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleoporin NUP170
UniProt: P38181
Pockets: 3 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 66% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A	Nucleoporin NUP170	protein	248	66% helix, 0% strand	P38181

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	303	0.56	0.76	41	empty
2	237	0.55	0.77	35	empty
3	181	0.52	0.78	28	empty

Interfaces

1 interface between chains.

B–A · 1242 Å² buried · 23 hydrogen bonds · protein-protein

Compared structures

3I5Q · Nup170(aa1253-1502) at 2.2 A, S.cerevisiae · the same entry in another collection · chain B against B, TM-score 1.00
P38181 · AlphaFold monomer V2.0 prediction for nucleoporin NUP170 (P38181) · a predicted model of the same protein · chain B against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P38181
Elsewhere: RCSB PDB 3I5Q · PDBe 3I5Q · UniProt P38181

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