MolNFT v1 · #66872 · protein
Crystal structure of the btb-back domains of human KLHL11
3I3N · Kelch-like protein 11: “Crystal structure of the btb-back domains of human KLHL11”. X-ray diffraction, 2 ligands (CL, SCN), 3 pockets (best druggability 0.52). MolNFT v1 #66872 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 3I3N
- Type
- protein
- Length
- 529 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kelch-like protein 11
- UniProt
- Q9NVR0
- Ligands
- CL, SCN
- Pockets
- 3 · best druggability 0.52
Structure
x-ray diffraction · 2 distinct chains · 58% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kelch-like protein 11 | protein | 262 | 59% helix, 8% strand | Q9NVR0 |
| B | Kelch-like protein 11 | protein | 267 | 57% helix, 8% strand | Q9NVR0 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 77 | 0.52 | 0.85 | 16 | empty |
| 2 | 88 | 0.45 | 0.80 | 16 | empty |
| 3 | 65 | 0.31 | 0.74 | 12 | CL |
Interfaces
1 interface between chains.
- A–B · 2398 Ų buried · 43 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NVR0
- Elsewhere: RCSB PDB 3I3N · PDBe 3I3N · UniProt Q9NVR0
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