MolNFT v1 · #66853 · protein
Crystal structure of the human 70KDA heat shock protein 2 (HSP70-2) ATPase domain in complex with ADP and inorganic phosphate
3I33 · Heat shock-related 70 kda protein 2: “Crystal structure of the human 70KDA heat shock protein 2 (HSP70-2) ATPase domain in complex with ADP and…”. X-ray diffraction, 3 ligands (ADP, MG, PO4), 1 pocket (best druggability 0.78).…
- PDB
- 3I33
- Type
- protein
- Length
- 380 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat shock-related 70 kda protein 2
- UniProt
- P54652
- Ligands
- ADP, MG, PO4
- Pockets
- 1 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heat shock-related 70 kda protein 2 | protein | 380 | 39% helix, 28% strand | P54652 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
- PO4 · Phosphate ion · ion · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 644 | 0.78 | 0.83 | 68 | PO4, ADP, MG |
Compared structures
- 3I33 · Crystal structure of the human 70kDa heat shock protein 2 (Hsp70-2) ATPase domain in… · the same entry in another collection · chain A against A, TM-score 1.00
- P54652 · AlphaFold monomer V2.0 prediction for heat shock-related 70 kda protein 2 (P54652) · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54652
- Elsewhere: RCSB PDB 3I33 · PDBe 3I33 · UniProt P54652
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