MolNFT v1 · #66827 · protein

Crystal structure of anti-il-23 antibody CNTO4088

3I2C · CNTO4088 light chain: “Crystal structure of anti-il-23 antibody CNTO4088”. X-ray diffraction, 4 pockets (best druggability 0.60). MolNFT v1 #66827 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3I2C
Type: protein
Length: 440 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CNTO4088 light chain; CNTO4088 heavy chain
Pockets: 4 · best druggability 0.60

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	CNTO4088 light chain	protein	218	6% helix, 51% strand	—
H	CNTO4088 heavy chain	protein	222	9% helix, 50% strand	—

Ligands and binding sites

GOL · Glycerol · additive · chains H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	495	0.60	0.75	52	empty
2	203	0.49	0.75	27	empty
3	132	0.44	0.76	27	empty
4	93	0.34	0.73	17	empty

Interfaces

1 interface between chains.

L–H · 1966 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

3I2C · Crystal structure of anti-IL-23 antibody CNTO4088 · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3I2C · PDBe 3I2C

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