MolNFT v1 · #66751 · protein

Tryptophanyl-tRNA synthetase homolog from entamoeba histolytica

3HZR: “Tryptophanyl-tRNA synthetase homolog from entamoeba histolytica”. X-ray diffraction, 20 pockets (best druggability 0.79). MolNFT v1 #66751 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3HZR
Type: protein
Length: 2,244 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tryptophanyl-tRNA synthetase
Pockets: 20 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 54% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F	Tryptophanyl-tRNA synthetase	protein	374	54% helix, 11% strand	—

Pockets

20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	859	0.79	0.82	74	empty
2	771	0.78	0.82	65	empty
3	715	0.78	0.82	68	empty
4	930	0.78	0.80	96	empty
5	668	0.78	0.82	54	empty

Interfaces

10 interfaces between chains.

C–D · 1465 Å² buried · 18 hydrogen bonds · protein-protein
A–B · 1439 Å² buried · 18 hydrogen bonds · protein-protein
E–F · 1439 Å² buried · 17 hydrogen bonds · protein-protein
A–D · 518 Å² buried · 2 hydrogen bonds · protein-protein
B–F · 516 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

3HZR · Tryptophanyl-tRNA synthetase homolog from Entamoeba histolytica · the same entry in another collection · chain E against E, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3HZR · PDBe 3HZR

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