MolNFT v1 · #66707 · protein
Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase SNF1
3HYH · Carbon catabolite-derepressing protein kinase: “Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase SNF1”. X-ray diffraction, 4 pockets (best druggability 0.66). MolNFT v1 #66707 on GenesisL1: 3D…
- PDB
- 3HYH
- Type
- protein
- Length
- 471 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Carbon catabolite-derepressing protein kinase
- EC
- 2.7.11.1
- UniProt
- P06782
- Pockets
- 4 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Carbon catabolite-derepressing protein kinase (EC 2.7.11.1) | protein | 238 | 40% helix, 18% strand | P06782 |
| B | Carbon catabolite-derepressing protein kinase (EC 2.7.11.1) | protein | 233 | 40% helix, 15% strand | P06782 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 483 | 0.66 | 0.78 | 48 | empty |
| 2 | 328 | 0.62 | 0.78 | 36 | empty |
| 3 | 166 | 0.46 | 0.76 | 31 | empty |
| 4 | 63 | 0.31 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 885 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 3HYH · Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase Snf1 · the same entry in another collection · chain A against A, TM-score 1.00
- P06782 · AlphaFold monomer V2.0 prediction for carbon catabolite-derepressing protein kinase… · a predicted model of the same protein · chain B against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06782
- Elsewhere: RCSB PDB 3HYH · PDBe 3HYH · UniProt P06782
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