MolNFT v1 · #66532 · protein
Zink containing polyketide cyclase remf from streptomyces resistomycificus
3HT2 · Remf protein: “Zink containing polyketide cyclase remf from streptomyces resistomycificus”. X-ray diffraction, 1 ligand (ZN), 3 pockets (best druggability 0.67). MolNFT v1 #66532 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 3HT2
- Type
- protein
- Length
- 286 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Remf protein
- UniProt
- Q70DX5
- Ligands
- ZN
- Pockets
- 3 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 13% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Remf protein | protein | 143 | 13% helix, 47% strand | Q70DX5 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 236 | 0.67 | 0.83 | 28 | empty |
| 2 | 255 | 0.65 | 0.82 | 28 | empty |
| 3 | 69 | 0.30 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–C · 1907 Ų buried · 35 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 3HT2 · Zink containing polyketide cyclase RemF from Streptomyces resistomycificus · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q70DX5
- Elsewhere: RCSB PDB 3HT2 · PDBe 3HT2 · UniProt Q70DX5
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