MolNFT v1 · #66504 · protein
Intersectin 1-peptide-AP2 beta ear complex
3HS9 · Ap-2 complex subunit beta-1: “Intersectin 1-peptide-AP2 beta ear complex”. X-ray diffraction, 2 pockets (best druggability 0.40). MolNFT v1 #66504 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3HS9
- Type
- protein
- Length
- 244 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ap-2 complex subunit beta-1; Peptide from intersectin-1, residues 841-851
- UniProt
- P62944, Q9Z0R4
- Pockets
- 2 · best druggability 0.40
Structure
x-ray diffraction · 2 distinct chains · 17% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ap-2 complex subunit beta-1 | protein | 233 | 18% helix, 38% strand | P62944 |
| P | Peptide from intersectin-1, residues 841-851 | protein | 11 | 0% helix, 0% strand | Q9Z0R4 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 117 | 0.40 | 0.75 | 21 | empty |
| 2 | 61 | 0.29 | 0.74 | 10 | empty |
Interfaces
1 interface between chains.
- A–P · 389 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 3HS9 · Intersectin 1-peptide-AP2 beta ear complex · the same entry in another collection · chain A against A, TM-score 1.00
- P62944 · AlphaFold monomer V2.0 prediction for ap-2 complex subunit beta (P62944) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q9Z0R4 · AlphaFold monomer V2.0 prediction for intersectin-1 (Q9Z0R4) · a predicted model of the same protein · chain P against A, TM-score 0.36
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62944
- Every structure of UniProt Q9Z0R4
- Elsewhere: RCSB PDB 3HS9 · PDBe 3HS9 · UniProt P62944 · UniProt Q9Z0R4
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