MolNFT v1 · #66244 · protein
Crystal structure of a cdpk kinase domain from cryptosporidium parvum, CGD7_40
3HKO · CALCIUM/CALMODULIN-dependent protein kinase with a kinase…: “Crystal structure of a cdpk kinase domain from cryptosporidium parvum, CGD7_40”. X-ray diffraction, 3 ligands (ANP, ZN, MG), 3 pockets (best druggability 0.67). MolNFT v1…
- PDB
- 3HKO
- Type
- protein
- Length
- 319 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CALCIUM/CALMODULIN-dependent protein kinase with a kinase domain and 2 calmodulin-like ef…
- UniProt
- Q5CZ29
- Ligands
- ANP, ZN, MG
- Pockets
- 3 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CALCIUM/CALMODULIN-dependent protein kinase with a kinase domain and 2 calmodulin-like ef hands | protein | 319 | 40% helix, 21% strand | Q5CZ29 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A
- ZN · Zinc ion · metal · chains A
- MG · Magnesium ion · metal · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 337 | 0.67 | 0.81 | 39 | ANP, MG |
| 2 | 64 | 0.36 | 0.78 | 16 | empty |
| 3 | 50 | 0.27 | 0.74 | 14 | empty |
Compared structures
- 3HKO · Crystal structure of a cdpk kinase domain from cryptosporidium Parvum, cgd7_40 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5CZ29
- Elsewhere: RCSB PDB 3HKO · PDBe 3HKO · UniProt Q5CZ29
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.