MolNFT v1 · #66222 · protein
Crystal structure of the ra and pH domains of GRB10
3HK0 · Growth factor receptor-bound protein 10: “Crystal structure of the ra and pH domains of GRB10”. X-ray diffraction, 1 ligand (SCN), 4 pockets (best druggability 0.80). MolNFT v1 #66222 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3HK0
- Type
- protein
- Length
- 446 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Growth factor receptor-bound protein 10
- UniProt
- Q13322
- Ligands
- SCN
- Pockets
- 4 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 23% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Growth factor receptor-bound protein 10 | protein | 230 | 25% helix, 36% strand | Q13322 |
| B | Growth factor receptor-bound protein 10 | protein | 216 | 22% helix, 34% strand | Q13322 |
Ligands and binding sites
- SCN · Thiocyanate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1043 | 0.80 | 0.82 | 86 | SCN |
| 2 | 217 | 0.65 | 0.84 | 30 | empty |
| 3 | 62 | 0.48 | 0.85 | 13 | empty |
| 4 | 60 | 0.34 | 0.78 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 842 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 3HK0 · Crystal Structure of the RA and PH Domains of Grb10 · the same entry in another collection · chain A against A, TM-score 1.00
- Q13322 · AlphaFold monomer V2.0 prediction for growth factor receptor-bound protein 10 (Q13322) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13322
- Elsewhere: RCSB PDB 3HK0 · PDBe 3HK0 · UniProt Q13322
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