MolNFT v1 · #66184 · protein
Minor editosome-associated tutase 1 with bound UTP and mg
3HIY: “Minor editosome-associated tutase 1 with bound UTP and mg”. X-ray diffraction, 2 ligands (UTP, MG), 7 pockets (best druggability 0.80). MolNFT v1 #66184 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3HIY
- Type
- protein
- Length
- 764 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Minor editosome-associated tutase
- UniProt
- Q4GZ86
- Ligands
- UTP, MG
- Pockets
- 7 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 57% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Minor editosome-associated tutase | protein | 382 | 57% helix, 9% strand | Q4GZ86 |
Ligands and binding sites
- UTP · Uridine 5'-triphosphate · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1033 | 0.80 | 0.81 | 83 | UTP, MG |
| 2 | 1058 | 0.79 | 0.81 | 81 | UTP |
| 3 | 458 | 0.74 | 0.83 | 57 | empty |
| 4 | 430 | 0.58 | 0.74 | 61 | empty |
| 5 | 56 | 0.30 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 677 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 24 modified (engineered).
Compared structures
- 3HIY · Minor Editosome-Associated TUTase 1 with bound UTP and Mg · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q4GZ86
- Elsewhere: RCSB PDB 3HIY · PDBe 3HIY · UniProt Q4GZ86
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