MolNFT v1 · #66159 · protein

Crystal structure of proliferating cell nuclear antigen (PCNA) from haloferax volcanii

3HI8 · Proliferating cell nuclear antigen PCNA: “Crystal structure of proliferating cell nuclear antigen (PCNA) from haloferax volcanii”. X-ray diffraction, 20 pockets (best druggability 0.82). MolNFT v1 #66159 on GenesisL1: 3D structure…

PDB: 3HI8
Type: protein
Length: 1,482 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proliferating cell nuclear antigen PCNA
Pockets: 20 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 17% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F	Proliferating cell nuclear antigen PCNA	protein	247	17% helix, 30% strand	—

Pockets

20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	172	0.82	0.96	35	empty
2	147	0.81	0.96	28	empty
3	140	0.81	0.97	25	empty
4	147	0.81	0.96	27	empty
5	141	0.81	0.96	26	empty

Interfaces

9 interfaces between chains.

B–C · 576 Å² buried · 10 hydrogen bonds · protein-protein
A–B · 571 Å² buried · 9 hydrogen bonds · protein-protein
D–E · 570 Å² buried · 9 hydrogen bonds · protein-protein
A–C · 570 Å² buried · 9 hydrogen bonds · protein-protein
E–F · 566 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

3HI8 · Crystal structure of proliferating cell nuclear antigen (PCNA) from Haloferax volcanii · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3HI8 · PDBe 3HI8

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