MolNFT v1 · #6615 · protein

The X-ray crystal structure of mevalonate 5-diphosphate decarboxylase at 2.3 ångström resolution.

1FI4: “The X-ray crystal structure of mevalonate 5-diphosphate decarboxylase at 2.3 ångström resolution.”. X-ray diffraction, 4 pockets (best druggability 0.66). MolNFT v1 #6615 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1FI4
Type: protein
Length: 391 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mevalonate 5-diphosphate decarboxylase
EC: 4.1.1.33
UniProt: P32377
Pockets: 4 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mevalonate 5-diphosphate decarboxylase (EC 4.1.1.33)	protein	391	40% helix, 20% strand	P32377

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	356	0.66	0.80	38	empty
2	86	0.40	0.78	13	empty
3	112	0.40	0.76	18	empty
4	63	0.28	0.73	12	empty

Modifications

Observed in the structure: 9 modified (engineered).

Compared structures

1FI4 · The X-ray crystal structure of mevalonate 5-diphosphate decarboxylase at 2.3 ångström… · the same entry in another collection · chain A against A, TM-score 1.00
P32377 · AlphaFold monomer V2.0 prediction for diphosphomevalonate decarboxylase (P32377) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P32377
Elsewhere: RCSB PDB 1FI4 · PDBe 1FI4 · UniProt P32377

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