MolNFT v1 · #65852 · protein

Crystal structure of the membrane fusion protein cusb from escherichia COLI

3H94 · Cation efflux system protein cusb: “Crystal structure of the membrane fusion protein cusb from escherichia COLI”. X-ray diffraction, 1 ligand (AG), 6 pockets (best druggability 0.63). MolNFT v1 #65852 on GenesisL1: 3D structure…

PDB: 3H94
Type: protein
Length: 594 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cation efflux system protein cusb
UniProt: P77239
Ligands: AG
Pockets: 6 · best druggability 0.63

Structure

x-ray diffraction · 1 distinct chain · 17% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Cation efflux system protein cusb	protein	297	17% helix, 39% strand	P77239

Ligands and binding sites

AG · Silver ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	118	0.63	0.87	24	empty
2	203	0.60	0.81	33	empty
3	72	0.53	0.86	24	empty
4	83	0.45	0.80	25	empty
5	118	0.43	0.76	19	empty

Interfaces

1 interface between chains.

A–B · 982 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

3H94 · Crystal structure of the membrane fusion protein CusB from Escherichia coli · the same entry in another collection · chain A against A, TM-score 1.00
P77239 · AlphaFold monomer V2.0 prediction for cation efflux system protein cusb (P77239) · a predicted model of the same protein · chain A against A, TM-score 0.80

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P77239
Elsewhere: RCSB PDB 3H94 · PDBe 3H94 · UniProt P77239

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