MolNFT v1 · #65703 · protein
Proteasome 20S core particle from methanocaldococcus jannaschii
3H4P · Proteasome subunit alpha: “Proteasome 20S core particle from methanocaldococcus jannaschii”. X-ray diffraction, 20 pockets (best druggability 0.72). MolNFT v1 #65703 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3H4P
- Type
- protein
- Length
- 6,076 residues
- Chains
- 28
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proteasome subunit alpha; Proteasome subunit beta
- EC
- 3.4.25.1
- UniProt
- Q60177, Q58634
- Pockets
- 20 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N | Proteasome subunit alpha (EC 3.4.25.1) | protein | 232 | 29% helix, 25% strand | Q60177 |
| a, b, c, d, e, f, g, h, i, j, k, l, m, n | Proteasome subunit beta (EC 3.4.25.1) | protein | 202 | 35% helix, 28% strand | Q58634 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 140 | 0.72 | 0.91 | 28 | empty |
| 2 | 123 | 0.72 | 0.92 | 30 | empty |
| 3 | 141 | 0.72 | 0.91 | 32 | empty |
| 4 | 145 | 0.71 | 0.90 | 32 | empty |
| 5 | 147 | 0.71 | 0.90 | 33 | empty |
Interfaces
56 interfaces between chains.
- D–E · 1393 Ų buried · 23 hydrogen bonds · protein-protein
- C–D · 1361 Ų buried · 23 hydrogen bonds · protein-protein
- J–K · 1349 Ų buried · 24 hydrogen bonds · protein-protein
- H–N · 1344 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 1343 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 3H4P · Proteasome 20S core particle from Methanocaldococcus jannaschii · the same entry in another collection · chain d against d, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q60177
- Every structure of UniProt Q58634
- Elsewhere: RCSB PDB 3H4P · PDBe 3H4P · UniProt Q60177 · UniProt Q58634
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