MolNFT v1 · #65402 · protein

Urod mutant G318R

3GW0 · Uroporphyrinogen decarboxylase: “Urod mutant G318R”. X-ray diffraction, 1 pocket (best druggability 0.73). MolNFT v1 #65402 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3GW0
Type: protein
Length: 356 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uroporphyrinogen decarboxylase
EC: 4.1.1.37
UniProt: P06132
Pockets: 1 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 52% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Uroporphyrinogen decarboxylase (EC 4.1.1.37)	protein	356	52% helix, 11% strand	P06132

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	495	0.73	0.81	41	empty

Compared structures

3GW0 · UROD mutant G318R · the same entry in another collection · chain A against A, TM-score 1.00
P06132 · AlphaFold monomer V2.0 prediction for uroporphyrinogen decarboxylase (P06132) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06132
Elsewhere: RCSB PDB 3GW0 · PDBe 3GW0 · UniProt P06132

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