MolNFT v1 · #64955 · protein
Crystal structure of the TNF-alpha inducing protein (tip alpha) from helicobacter pylori
3GIO · Putative uncharacterized protein: “Crystal structure of the TNF-alpha inducing protein (tip alpha) from helicobacter pylori”. X-ray diffraction, 2 pockets (best druggability 0.69). MolNFT v1 #64955 on GenesisL1: 3D structure…
- PDB
- 3GIO
- Type
- protein
- Length
- 296 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative uncharacterized protein
- UniProt
- O25318
- Pockets
- 2 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 49% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Putative uncharacterized protein | protein | 148 | 49% helix, 23% strand | O25318 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 636 | 0.69 | 0.78 | 34 | empty |
| 2 | 124 | 0.43 | 0.77 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1618 Ų buried · 37 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
- 3GIO · Crystal structure of the TNF-alpha inducing protein (Tip alpha) from Helicobacter pylori · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O25318
- Elsewhere: RCSB PDB 3GIO · PDBe 3GIO · UniProt O25318
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