MolNFT v1 · #64654 · protein
Crystal structure of a soluble decoy receptor il-22BP bound to interleukin-22
3G9V · Interleukin 22 receptor, alpha 2: “Crystal structure of a soluble decoy receptor il-22BP bound to interleukin-22”. X-ray diffraction, 5 pockets (best druggability 0.64). MolNFT v1 #64654 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3G9V
- Type
- protein
- Length
- 613 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin 22 receptor, alpha 2; Interleukin-22
- UniProt
- Q08AH7, Q9GZX6
- Pockets
- 5 · best druggability 0.64
Structure
x-ray diffraction · 4 distinct chains · 34% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interleukin 22 receptor, alpha 2 | protein | 173 | 9% helix, 45% strand | Q08AH7 |
| B | Interleukin-22 | protein | 134 | 67% helix, 0% strand | Q9GZX6 |
| C | Interleukin 22 receptor, alpha 2 | protein | 176 | 9% helix, 42% strand | Q08AH7 |
| D | Interleukin-22 | protein | 130 | 69% helix, 0% strand | Q9GZX6 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 371 | 0.64 | 0.79 | 49 | empty |
| 2 | 348 | 0.62 | 0.78 | 44 | empty |
| 3 | 189 | 0.49 | 0.76 | 30 | empty |
| 4 | 123 | 0.44 | 0.77 | 22 | empty |
| 5 | 153 | 0.44 | 0.75 | 30 | empty |
Interfaces
3 interfaces between chains.
- A–B · 973 Ų buried · 21 hydrogen bonds · protein-protein
- C–D · 968 Ų buried · 22 hydrogen bonds · protein-protein
- A–C · 900 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 3G9V · Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9GZX6 · AlphaFold monomer V2.0 prediction for interleukin-22 (Q9GZX6) · a predicted model of the same protein · chain D against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q08AH7
- Every structure of UniProt Q9GZX6
- Elsewhere: RCSB PDB 3G9V · PDBe 3G9V · UniProt Q08AH7 · UniProt Q9GZX6
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