MolNFT v1 · #64554 · protein + DNA
Gr gamma DNA-binding DOMAIN:FKBP5 16BP complex-34
3G6T · Glucocorticoid receptor: “Gr gamma DNA-binding DOMAIN:FKBP5 16BP complex-34”. X-ray diffraction, 1 ligand (ZN), 4 pockets (best druggability 0.68). MolNFT v1 #64554 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3G6T
- Type
- protein + DNA
- Length
- 182 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glucocorticoid receptor; DNA (5'-D(*TP*AP*GP*AP*AP*CP*AP*CP*CP*CP*TP*GP*TP*TP*CP*T)- 3')…
- UniProt
- P06536
- Ligands
- ZN
- Pockets
- 4 · best druggability 0.68
Structure
x-ray diffraction · 4 distinct chains · 33% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glucocorticoid receptor | protein | 78 | 32% helix, 10% strand | P06536 |
| B | Glucocorticoid receptor | protein | 72 | 35% helix, 6% strand | P06536 |
| D | DNA (5'-D(*TP*AP*GP*AP*AP*CP*AP*CP*CP*CP*TP*GP*TP*TP*CP*T)- 3') | dna | 16 | — | — |
| C | DNA (5'-D(*AP*AP*GP*AP*AP*CP*AP*GP*GP*GP*TP*GP*TP*TP*CP*T)- 3') | dna | 16 | — | — |
Ligands and binding sites
- ZN · Zinc ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 486 | 0.68 | 0.80 | 35 | empty |
| 2 | 157 | 0.48 | 0.77 | 30 | empty |
| 3 | 95 | 0.39 | 0.77 | 19 | empty |
| 4 | 63 | 0.31 | 0.75 | 16 | empty |
Interfaces
6 interfaces between chains.
- D–C · 633 Ų buried · 60 hydrogen bonds · nucleic-nucleic
- A–B · 593 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 389 Ų buried · 6 hydrogen bonds · protein-nucleic
- A–C · 361 Ų buried · 7 hydrogen bonds · protein-nucleic
- A–D · 360 Ų buried · 7 hydrogen bonds · protein-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06536
- Elsewhere: RCSB PDB 3G6T · PDBe 3G6T · UniProt P06536
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.