MolNFT v1 · #64537 · protein

Crystal structure of anti-il-13 antibody CNTO607

3G6A · CNTO607 Fab light chain: “Crystal structure of anti-il-13 antibody CNTO607”. X-ray diffraction, 12 pockets (best druggability 0.58). MolNFT v1 #64537 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3G6A
Type: protein
Length: 864 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CNTO607 Fab light chain; CNTO607 Fab heavy chain
Pockets: 12 · best druggability 0.58

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L, A	CNTO607 Fab light chain	protein	210	8% helix, 51% strand	—
H, B	CNTO607 Fab heavy chain	protein	222	8% helix, 50% strand	—

Pockets

12 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	457	0.58	0.74	52	empty
2	312	0.51	0.73	48	empty
3	269	0.50	0.74	40	empty
4	165	0.48	0.77	29	empty
5	145	0.44	0.76	25	empty

Interfaces

4 interfaces between chains.

L–H · 1702 Å² buried · 18 hydrogen bonds · protein-protein
A–B · 1669 Å² buried · 16 hydrogen bonds · protein-protein
H–B · 515 Å² buried · 7 hydrogen bonds · protein-protein
H–A · 360 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

3G6A · Crystal structure of anti-IL-13 antibody CNTO607 · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3G6A · PDBe 3G6A

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