MolNFT v1 · #64527 · protein

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR

3G5Y · 175 light chain: “Antibodies specifically targeting a locally misfolded region of tumor associated EGFR”. X-ray diffraction, 1 pocket (best druggability 0.58). MolNFT v1 #64527 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 3G5Y
Type: protein
Length: 439 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 175 light chain; 175 heavy chain; EGFR peptide
Pockets: 1 · best druggability 0.58

Structure

x-ray diffraction · 3 distinct chains · 5% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	175 light chain	protein	213	5% helix, 52% strand	—
B	175 heavy chain	protein	210	6% helix, 53% strand	—
E	EGFR peptide	protein	16	0% helix, 38% strand	—

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	498	0.58	0.73	60	empty

Interfaces

3 interfaces between chains.

A–B · 1894 Å² buried · 13 hydrogen bonds · protein-protein
B–E · 387 Å² buried · 9 hydrogen bonds · protein-protein
A–E · 323 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

3G5Y · Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3G5Y · PDBe 3G5Y

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