MolNFT v1 · #64509 · protein
Crystal structure of the wild-type restriction-modification controller protein C.ESP1396I
3G5G · Regulatory protein: “Crystal structure of the wild-type restriction-modification controller protein C.ESP1396I”. X-ray diffraction, 10 pockets (best druggability 0.58). MolNFT v1 #64509 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3G5G
- Type
- protein
- Length
- 1,074 residues
- Chains
- 14
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Regulatory protein
- UniProt
- Q8GGH0
- Pockets
- 10 · best druggability 0.58
Structure
x-ray diffraction · 6 distinct chains · 73% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, G, K, L | Regulatory protein | protein | 76 | 72% helix, 1% strand | Q8GGH0 |
| B, H, J | Regulatory protein | protein | 78 | 72% helix, 1% strand | Q8GGH0 |
| D | Regulatory protein | protein | 77 | 73% helix, 1% strand | Q8GGH0 |
| E, F, I | Regulatory protein | protein | 77 | 71% helix, 1% strand | Q8GGH0 |
| M | Regulatory protein | protein | 77 | 73% helix, 1% strand | Q8GGH0 |
| N | Regulatory protein | protein | 75 | 75% helix, 1% strand | Q8GGH0 |
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 353 | 0.58 | 0.76 | 43 | empty |
| 2 | 398 | 0.56 | 0.74 | 43 | empty |
| 3 | 202 | 0.55 | 0.79 | 24 | empty |
| 4 | 216 | 0.50 | 0.76 | 21 | empty |
| 5 | 205 | 0.49 | 0.76 | 33 | empty |
Interfaces
24 interfaces between chains.
- G–H · 1058 Ų buried · 9 hydrogen bonds · protein-protein
- K–L · 1054 Ų buried · 8 hydrogen bonds · protein-protein
- I–J · 1052 Ų buried · 9 hydrogen bonds · protein-protein
- M–N · 1048 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 1047 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 3G5G · Crystal Structure of the Wild-Type Restriction-Modification Controller Protein C.Esp1396I · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8GGH0
- Elsewhere: RCSB PDB 3G5G · PDBe 3G5G · UniProt Q8GGH0
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