MolNFT v1 · #64504 · protein

The structure of UNC5B cytoplasmic domain

3G5B · Netrin receptor UNC5B: “The structure of UNC5B cytoplasmic domain”. X-ray diffraction, 1 ligand (PO4), 3 pockets (best druggability 0.72). MolNFT v1 #64504 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3G5B
Type: protein
Length: 383 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Netrin receptor UNC5B
UniProt: O08722
Ligands: PO4
Pockets: 3 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 20% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Netrin receptor UNC5B	protein	383	20% helix, 37% strand	O08722

Ligands and binding sites

PO4 · Phosphate ion · ion · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	196	0.72	0.89	34	empty
2	107	0.37	0.74	31	empty
3	56	0.30	0.76	10	empty

Compared structures

3G5B · The structure of UNC5b cytoplasmic domain · the same entry in another collection · chain A against A, TM-score 1.00
O08722 · AlphaFold monomer V2.0 prediction for netrin receptor UNC5B (O08722) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O08722
Elsewhere: RCSB PDB 3G5B · PDBe 3G5B · UniProt O08722

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