MolNFT v1 · #64326 · protein

Structure of grc mutant E192R/E193G

3G01 · Granzyme C: “Structure of grc mutant E192R/E193G”. X-ray diffraction, 2 pockets (best druggability 0.70). MolNFT v1 #64326 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3G01
Type: protein
Length: 420 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Granzyme C
EC: 3.4.21.-
UniProt: P08882
Pockets: 2 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 9% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Granzyme C (EC 3.4.21.-)	protein	211	9% helix, 41% strand	P08882
B	Granzyme C (EC 3.4.21.-)	protein	209	10% helix, 42% strand	P08882

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	893	0.70	0.75	79	empty
2	53	0.36	0.79	16	empty

Interfaces

1 interface between chains.

A–B · 531 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

3G01 · Structure of GrC mutant E192R/E193G · the same entry in another collection · chain A against A, TM-score 1.00
P08882 · AlphaFold monomer V2.0 prediction for granzyme C (P08882) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08882
Elsewhere: RCSB PDB 3G01 · PDBe 3G01 · UniProt P08882

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