MolNFT v1 · #64300 · protein

Crystal structure of the tail terminator protein from phage lambda (gpu-wt)

3FZB · Minor tail protein U: “Crystal structure of the tail terminator protein from phage lambda (gpu-wt)”. X-ray diffraction, 1 ligand (SO4), 13 pockets (best druggability 0.75). MolNFT v1 #64300 on GenesisL1: 3D structure, binding sites…

PDB: 3FZB
Type: protein
Length: 1,289 residues
Chains: 10
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Minor tail protein U
UniProt: P03732
Ligands: SO4
Pockets: 13 · best druggability 0.75

Structure

x-ray diffraction · 10 distinct chains · 28% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Minor tail protein U	protein	130	28% helix, 42% strand	P03732
B	Minor tail protein U	protein	130	31% helix, 40% strand	P03732
C	Minor tail protein U	protein	129	27% helix, 42% strand	P03732
D	Minor tail protein U	protein	129	28% helix, 40% strand	P03732
E	Minor tail protein U	protein	128	30% helix, 42% strand	P03732
F	Minor tail protein U	protein	130	28% helix, 45% strand	P03732
G	Minor tail protein U	protein	132	27% helix, 40% strand	P03732
H	Minor tail protein U	protein	129	29% helix, 40% strand	P03732
I	Minor tail protein U	protein	127	31% helix, 43% strand	P03732
J	Minor tail protein U	protein	125	26% helix, 43% strand	P03732

Ligands and binding sites

SO4 · Sulfate ion · ion · 3 copies · chains D, F, H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

13 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	878	0.75	0.79	104	empty
2	421	0.62	0.76	41	empty
3	362	0.60	0.77	58	empty
4	277	0.55	0.76	41	empty
5	249	0.52	0.76	41	empty

Interfaces

18 interfaces between chains.

C–E · 660 Å² buried · 11 hydrogen bonds · protein-protein
B–I · 630 Å² buried · 14 hydrogen bonds · protein-protein
A–F · 623 Å² buried · 11 hydrogen bonds · protein-protein
A–B · 617 Å² buried · 12 hydrogen bonds · protein-protein
C–D · 616 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

3FZB · Crystal structure of the tail terminator protein from phage lambda (gpU-WT) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03732
Elsewhere: RCSB PDB 3FZB · PDBe 3FZB · UniProt P03732

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