MolNFT v1 · #63969 · protein

Crystal structure of E.COLI maca

3FPP · Macrolide-specific efflux protein maca: “Crystal structure of E.COLI maca”. X-ray diffraction, 5 pockets (best druggability 0.56). MolNFT v1 #63969 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3FPP
Type: protein
Length: 533 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Macrolide-specific efflux protein maca
UniProt: P75830
Pockets: 5 · best druggability 0.56

Structure

x-ray diffraction · 2 distinct chains · 29% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Macrolide-specific efflux protein maca	protein	266	28% helix, 27% strand	P75830
B	Macrolide-specific efflux protein maca	protein	267	30% helix, 30% strand	P75830

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	128	0.56	0.83	19	empty
2	330	0.54	0.74	32	empty
3	185	0.52	0.78	29	empty
4	91	0.35	0.75	23	empty
5	68	0.29	0.73	20	empty

Interfaces

1 interface between chains.

A–B · 2011 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

3FPP · Crystal structure of E.coli MacA · the same entry in another collection · chain A against A, TM-score 1.00
P75830 · AlphaFold monomer V2.0 prediction for macrolide export protein maca (P75830) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P75830
Elsewhere: RCSB PDB 3FPP · PDBe 3FPP · UniProt P75830

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