MolNFT v1 · #639 · protein
Fab fragment of engineered human monoclonal antibody A5B7
1AD0 · Antibody A5B7 (light chain): “Fab fragment of engineered human monoclonal antibody A5B7”. X-ray diffraction, 11 pockets (best druggability 0.61). MolNFT v1 #639 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1AD0
- Type
- protein
- Length
- 866 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Antibody A5B7 (light chain); Antibody A5B7 (heavy chain)
- Pockets
- 11 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Antibody A5B7 (light chain) | protein | 213 | 5% helix, 54% strand | — |
| B, D | Antibody A5B7 (heavy chain) | protein | 220 | 7% helix, 51% strand | — |
Pockets
11 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 610 | 0.61 | 0.73 | 65 | empty |
| 2 | 536 | 0.60 | 0.74 | 55 | empty |
| 3 | 53 | 0.47 | 0.86 | 22 | empty |
| 4 | 99 | 0.44 | 0.79 | 19 | empty |
| 5 | 107 | 0.43 | 0.77 | 22 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1870 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 1866 Ų buried · 15 hydrogen bonds · protein-protein
- B–C · 328 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 1AD0 · Fab fragment of engineered human monoclonal antibody A5B7 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1AD0 · PDBe 1AD0
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