MolNFT v1 · #63883 · protein
E2-ring expansion of the NEDD8 cascade confers specificity to cullin modification.
3FN1 · NEDD8-activating enzyme E1 catalytic subunit: “E2-ring expansion of the NEDD8 cascade confers specificity to cullin modification.”. X-ray diffraction. MolNFT v1 #63883 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3FN1
- Type
- protein
- Length
- 252 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NEDD8-activating enzyme E1 catalytic subunit; NEDD8-conjugating enzyme UBE2F
- EC
- 6.3.2.-
- UniProt
- Q8TBC4, Q969M7
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) | protein | 92 | 24% helix, 35% strand | Q8TBC4 |
| B | NEDD8-conjugating enzyme UBE2F (EC 6.3.2.-) | protein | 160 | 33% helix, 16% strand | Q969M7 |
Interfaces
1 interface between chains.
- A–B · 987 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (engineered).
Compared structures
- 3FN1 · E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. · the same entry in another collection · chain A against A, TM-score 1.00
- Q969M7 · AlphaFold monomer V2.0 prediction for NEDD8-conjugating enzyme UBE2F (Q969M7) · a predicted model of the same protein · chain B against A, TM-score 0.98
- Q8TBC4 · AlphaFold monomer V2.0 prediction for NEDD8-activating enzyme E1 catalytic subunit… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8TBC4
- Every structure of UniProt Q969M7
- Elsewhere: RCSB PDB 3FN1 · PDBe 3FN1 · UniProt Q8TBC4 · UniProt Q969M7
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