MolNFT v1 · #63780 · protein

Structure of the yeats domain, YAF9

3FK3 · Protein af-9 homolog: “Structure of the yeats domain, YAF9”. X-ray diffraction, 1 pocket (best druggability 0.70). MolNFT v1 #63780 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3FK3
Type: protein
Length: 420 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein af-9 homolog
UniProt: P53930
Pockets: 1 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 11% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Protein af-9 homolog	protein	140	11% helix, 51% strand	P53930

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	816	0.70	0.76	60	empty

Interfaces

3 interfaces between chains.

A–C · 713 Å² buried · 15 hydrogen bonds · protein-protein
A–B · 708 Å² buried · 17 hydrogen bonds · protein-protein
B–C · 698 Å² buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

3FK3 · Structure of the Yeats Domain, Yaf9 · the same entry in another collection · chain A against A, TM-score 1.00
P53930 · AlphaFold monomer V2.0 prediction for protein af-9 homolog (P53930) · a predicted model of the same protein · chain C against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P53930
Elsewhere: RCSB PDB 3FK3 · PDBe 3FK3 · UniProt P53930

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