MolNFT v1 · #63669 · protein

2.05 a crystal structure of cysm from mycobacterium tuberculosis - open and closed conformations

3FGP · Cysteine synthase B: “2.05 a crystal structure of cysm from mycobacterium tuberculosis - open and closed conformations”. X-ray diffraction, 5 pockets (best druggability 0.76). MolNFT v1 #63669 on GenesisL1: 3D structure, binding…

PDB: 3FGP
Type: protein
Length: 636 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cysteine synthase B
EC: 2.5.1.65
UniProt: P63873
Pockets: 5 · best druggability 0.76

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cysteine synthase B (EC 2.5.1.65)	protein	312	41% helix, 20% strand	P63873
B	Cysteine synthase B (EC 2.5.1.65)	protein	324	38% helix, 20% strand	P63873

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	107	0.76	0.96	31	empty
2	766	0.74	0.79	81	empty
3	166	0.57	0.81	21	empty
4	159	0.43	0.74	22	empty
5	66	0.29	0.74	14	empty

Interfaces

1 interface between chains.

A–B · 2066 Å² buried · 27 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (cofactor).

Compared structures

3FGP · 2.05 a Crystal Structure of CysM from Mycobacterium Tuberculosis - Open and Closed… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P63873
Elsewhere: RCSB PDB 3FGP · PDBe 3FGP · UniProt P63873

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