MolNFT v1 · #63658 · protein
The crystal structure of an universal stress protein uspa family protein from lactobacillus plantarum WCFS1
3FG9 · Protein of universal stress protein uspa family: “The crystal structure of an universal stress protein uspa family protein from lactobacillus plantarum WCFS1”. X-ray diffraction, 1 ligand (MG), 6 pockets (best druggability 0.71).…
- PDB
- 3FG9
- Type
- protein
- Length
- 893 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein of universal stress protein uspa family
- UniProt
- Q88RY8
- Ligands
- MG
- Pockets
- 6 · best druggability 0.71
Structure
x-ray diffraction · 5 distinct chains · 45% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein of universal stress protein uspa family | protein | 156 | 46% helix, 18% strand | Q88RY8 |
| B | Protein of universal stress protein uspa family | protein | 146 | 46% helix, 21% strand | Q88RY8 |
| C, E | Protein of universal stress protein uspa family | protein | 150 | 42% helix, 20% strand | Q88RY8 |
| D | Protein of universal stress protein uspa family | protein | 150 | 46% helix, 20% strand | Q88RY8 |
| F | Protein of universal stress protein uspa family | protein | 141 | 47% helix, 21% strand | Q88RY8 |
Ligands and binding sites
- MG · Magnesium ion · metal · 7 copies · chains A, E, B, C, D, F
- FMT · Formic acid · additive · 7 copies · chains A, B, C, D
- ACT · Acetate ion · additive · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 50 | 0.71 | 0.98 | 15 | empty |
| 2 | 450 | 0.71 | 0.81 | 64 | MG |
| 3 | 535 | 0.71 | 0.80 | 62 | FMT, MG |
| 4 | 76 | 0.40 | 0.79 | 15 | empty |
| 5 | 59 | 0.34 | 0.77 | 16 | empty |
Interfaces
9 interfaces between chains.
- A–B · 1982 Ų buried · 43 hydrogen bonds · protein-protein
- E–F · 1779 Ų buried · 44 hydrogen bonds · protein-protein
- C–D · 1760 Ų buried · 38 hydrogen bonds · protein-protein
- A–E · 511 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 487 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 3FG9 · The crystal structure of an universal stress protein UspA family protein from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q88RY8
- Elsewhere: RCSB PDB 3FG9 · PDBe 3FG9 · UniProt Q88RY8
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