MolNFT v1 · #63604 · protein

The crystal structure of MBTD1

3FEO · Mbt domain-containing protein 1: “The crystal structure of MBTD1”. X-ray diffraction, 10 pockets (best druggability 0.86). MolNFT v1 #63604 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3FEO
Type: protein
Length: 804 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mbt domain-containing protein 1
UniProt: Q05BQ5
Pockets: 10 · best druggability 0.86

Structure

x-ray diffraction · 2 distinct chains · 17% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mbt domain-containing protein 1	protein	407	18% helix, 32% strand	Q05BQ5
B	Mbt domain-containing protein 1	protein	397	16% helix, 31% strand	Q05BQ5

Pockets

10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1146	0.86	0.86	111	empty
2	719	0.78	0.83	66	empty
3	555	0.76	0.84	38	empty
4	673	0.68	0.76	52	empty
5	118	0.46	0.78	17	empty

Interfaces

1 interface between chains.

A–B · 1194 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

3FEO · The crystal structure of MBTD1 · the same entry in another collection · chain A against A, TM-score 1.00
Q05BQ5 · AlphaFold monomer V2.0 prediction for mbt domain-containing protein 1 (Q05BQ5) · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q05BQ5
Elsewhere: RCSB PDB 3FEO · PDBe 3FEO · UniProt Q05BQ5

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