MolNFT v1 · #63584 · protein
Crystal structure of the kinase MARK3/PAR-1: T211A-S215A double mutant
3FE3 · MAP/MICROTUBULE affinity-regulating kinase 3: “Crystal structure of the kinase MARK3/PAR-1: T211A-S215A double mutant”. X-ray diffraction, 7 pockets (best druggability 0.75). MolNFT v1 #63584 on GenesisL1: 3D structure, binding…
- PDB
- 3FE3
- Type
- protein
- Length
- 634 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MAP/MICROTUBULE affinity-regulating kinase 3
- EC
- 2.7.11.1
- UniProt
- P27448
- Pockets
- 7 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | MAP/MICROTUBULE affinity-regulating kinase 3 (EC 2.7.11.1) | protein | 317 | 42% helix, 15% strand | P27448 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 665 | 0.75 | 0.81 | 78 | empty |
| 2 | 305 | 0.71 | 0.84 | 35 | empty |
| 3 | 175 | 0.45 | 0.74 | 21 | empty |
| 4 | 95 | 0.43 | 0.79 | 19 | empty |
| 5 | 145 | 0.40 | 0.74 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1370 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 3FE3 · Crystal structure of the kinase MARK3/Par-1: T211A-S215A double mutant · the same entry in another collection · chain A against A, TM-score 1.00
- P27448 · AlphaFold monomer V2.0 prediction for MAP/MICROTUBULE affinity- regulating kinase 3… · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P27448
- Elsewhere: RCSB PDB 3FE3 · PDBe 3FE3 · UniProt P27448
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