MolNFT v1 · #63487 · protein
Kcsa potassium channel in the open-conductive state with 20 a opening at T112 in the presence of rb+ ion
3FB8 · Antibody Fab fragment heavy chain: “Kcsa potassium channel in the open-conductive state with 20 a opening at T112 in the presence of rb+ ion”. X-ray diffraction, 1 ligand (RB), 6 pockets (best druggability 0.69). MolNFT v1 #63487 on…
- PDB
- 3FB8
- Type
- protein
- Length
- 518 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Antibody Fab fragment heavy chain; Antibody Fab fragment light chain; Voltage-gated…
- UniProt
- P0A334
- Ligands
- RB
- Pockets
- 6 · best druggability 0.69
Structure
x-ray diffraction · 3 distinct chains · 16% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Antibody Fab fragment heavy chain | protein | 219 | 5% helix, 51% strand | — |
| B | Antibody Fab fragment light chain | protein | 212 | 6% helix, 51% strand | — |
| C | Voltage-gated potassium channel | protein | 87 | 69% helix, 0% strand | P0A334 |
Ligands and binding sites
- RB · Rubidium ion · metal · 4 copies · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 767 | 0.69 | 0.76 | 63 | empty |
| 2 | 62 | 0.61 | 0.91 | 17 | empty |
| 3 | 166 | 0.53 | 0.79 | 27 | empty |
| 4 | 53 | 0.49 | 0.87 | 21 | empty |
| 5 | 79 | 0.47 | 0.82 | 20 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1847 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 493 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 397 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 3FB8 · KcsA Potassium channel in the open-conductive state with 20 A opening at T112 in the… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A334
- Elsewhere: RCSB PDB 3FB8 · PDBe 3FB8 · UniProt P0A334
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.