MolNFT v1 · #63430 · protein

Crystal structure of the F140A mutant of SARS-coronovirus 3C-like protease at pH 7.6

3F9H · 3C-like proteinase: “Crystal structure of the F140A mutant of SARS-coronovirus 3C-like protease at pH 7.6”. X-ray diffraction, 8 pockets (best druggability 0.77). MolNFT v1 #63430 on GenesisL1: 3D structure, binding sites and…

PDB: 3F9H
Type: protein
Length: 599 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 3C-like proteinase
EC: 3.4.22.-
UniProt: P0C6U8
Pockets: 8 · best druggability 0.77

Structure

x-ray diffraction · 2 distinct chains · 25% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	3C-like proteinase (EC 3.4.22.-)	protein	299	25% helix, 30% strand	P0C6U8
B	3C-like proteinase (EC 3.4.22.-)	protein	300	25% helix, 30% strand	P0C6U8

Pockets

8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	958	0.77	0.80	80	empty
2	259	0.49	0.74	33	empty
3	153	0.45	0.76	26	empty
4	117	0.37	0.74	23	empty
5	113	0.36	0.73	19	empty

Interfaces

1 interface between chains.

A–B · 1273 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

3F9H · Crystal Structure of the F140A mutant of SARS-Coronovirus 3C-like Protease at pH 7.6 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0C6U8
Elsewhere: RCSB PDB 3F9H · PDBe 3F9H · UniProt P0C6U8

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