MolNFT v1 · #6336 · protein

Crystal structure of streptococcus pneumoniae hyaluronate lyase cocrystallized with ascorbic acid

1F9G: “Crystal structure of streptococcus pneumoniae hyaluronate lyase cocrystallized with ascorbic acid”. X-ray diffraction, 1 ligand (ASC), 12 pockets (best druggability 0.72). MolNFT v1 #6336 on GenesisL1: 3D structure, binding sites…

PDB: 1F9G
Type: protein
Length: 721 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hyaluronate lyase
EC: 4.2.2.1
UniProt: Q54873
Ligands: ASC
Pockets: 12 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hyaluronate lyase (EC 4.2.2.1)	protein	721	36% helix, 26% strand	Q54873

Ligands and binding sites

ASC · Ascorbic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

12 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	853	0.72	0.77	68	ASC
2	51	0.70	0.98	22	empty
3	95	0.43	0.78	18	empty
4	53	0.42	0.83	20	empty
5	77	0.39	0.78	16	empty

Compared structures

1F9G · Crystal structure of streptococcus pneumoniae hyaluronate lyase cocrystallized with… · the same entry in another collection · chain A against A, TM-score 1.00
Q54873 · AlphaFold monomer V2.0 prediction for hyaluronate lyase (Q54873) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q54873
Elsewhere: RCSB PDB 1F9G · PDBe 1F9G · UniProt Q54873

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