MolNFT v1 · #63322 · protein
Crystal structure of N-terminal domain of positive transcription regulator evga from escherichia COLI
3F6C: “Crystal structure of N-terminal domain of positive transcription regulator evga from escherichia COLI”. X-ray diffraction, 2 pockets (best druggability 0.54). MolNFT v1 #63322 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 3F6C
- Type
- protein
- Length
- 257 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Positive transcription regulator evga
- UniProt
- P0ACZ4
- Pockets
- 2 · best druggability 0.54
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Positive transcription regulator evga | protein | 129 | 42% helix, 22% strand | P0ACZ4 |
| B | Positive transcription regulator evga | protein | 128 | 40% helix, 23% strand | P0ACZ4 |
Ligands and binding sites
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 129 | 0.54 | 0.82 | 27 | empty |
| 2 | 57 | 0.34 | 0.78 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 428 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 3F6C · CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF POSITIVE TRANSCRIPTION REGULATOR evgA FROM… · the same entry in another collection · chain A against A, TM-score 1.00
- P0ACZ4 · AlphaFold monomer V2.0 prediction for DNA-binding transcriptional activator evga (P0ACZ4) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0ACZ4
- Elsewhere: RCSB PDB 3F6C · PDBe 3F6C · UniProt P0ACZ4
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