MolNFT v1 · #63240 · protein

The crystal structure of human lambda-crystallin, CRYL1

3F3S · Lambda-crystallin homolog: “The crystal structure of human lambda-crystallin, CRYL1”. X-ray diffraction, 3 ligands (NAD, SO4, CL), 9 pockets (best druggability 0.77). MolNFT v1 #63240 on GenesisL1: 3D structure, binding sites and…

PDB: 3F3S
Type: protein
Length: 623 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lambda-crystallin homolog
UniProt: Q9Y2S2
Ligands: NAD, SO4, CL
Pockets: 9 · best druggability 0.77

Structure

x-ray diffraction · 2 distinct chains · 55% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Lambda-crystallin homolog	protein	312	55% helix, 11% strand	Q9Y2S2
B	Lambda-crystallin homolog	protein	311	55% helix, 12% strand	Q9Y2S2

Ligands and binding sites

NAD · Nicotinamide-adenine-dinucleotide · ligand · 2 copies · chains A, B
SO4 · Sulfate ion · ion · 4 copies · chains A, B
CL · Chloride ion · ion · 4 copies · chains A, B
GOL · Glycerol · additive · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	576	0.77	0.83	60	NAD, SO4, GOL
2	426	0.67	0.80	45	NAD, SO4
3	225	0.55	0.77	23	empty
4	139	0.53	0.81	20	empty
5	209	0.51	0.77	38	empty

Interfaces

1 interface between chains.

A–B · 5344 Å² buried · 52 hydrogen bonds · protein-protein

Compared structures

3F3S · The Crystal Structure of Human Lambda-Crystallin, CRYL1 · the same entry in another collection · chain A against A, TM-score 1.00
Q9Y2S2 · AlphaFold monomer V2.0 prediction for lambda-crystallin homolog (Q9Y2S2) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y2S2
Elsewhere: RCSB PDB 3F3S · PDBe 3F3S · UniProt Q9Y2S2

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