MolNFT v1 · #63218 · protein
Crystal structure of the N-terminal region of alphaii-spectrin tetramerization domain
3F31 · Spectrin alpha chain, brain: “Crystal structure of the N-terminal region of alphaii-spectrin tetramerization domain”. X-ray diffraction, 6 pockets (best druggability 0.72). MolNFT v1 #63218 on GenesisL1: 3D structure, binding sites…
- PDB
- 3F31
- Type
- protein
- Length
- 277 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Spectrin alpha chain, brain
- UniProt
- Q13813
- Pockets
- 6 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 81% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Spectrin alpha chain, brain | protein | 137 | 82% helix, 0% strand | Q13813 |
| B | Spectrin alpha chain, brain | protein | 140 | 81% helix, 0% strand | Q13813 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 286 | 0.72 | 0.86 | 33 | empty |
| 2 | 53 | 0.46 | 0.85 | 17 | empty |
| 3 | 102 | 0.46 | 0.79 | 20 | empty |
| 4 | 124 | 0.44 | 0.76 | 24 | empty |
| 5 | 96 | 0.42 | 0.78 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1623 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 3F31 · Crystal Structure of the N-terminal region of AlphaII-spectrin Tetramerization Domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q13813 · AlphaFold monomer V2.0 prediction for spectrin alpha chain, non- erythrocytic 1 (Q13813) · a predicted model of the same protein · chain A against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13813
- Elsewhere: RCSB PDB 3F31 · PDBe 3F31 · UniProt Q13813
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