MolNFT v1 · #6320 · protein
Fab fragment of monoclonal antibody (lnkb-2) against human interleukin-2 in complex with antigenic peptide
1F90: “Fab fragment of monoclonal antibody (lnkb-2) against human interleukin-2 in complex with antigenic peptide”. X-ray diffraction, 3 pockets (best druggability 0.56). MolNFT v1 #6320 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1F90
- Type
- protein
- Length
- 448 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fab fragment of monoclonal antibody; Antigenic nonapeptide
- Pockets
- 3 · best druggability 0.56
Structure
x-ray diffraction · 3 distinct chains · 6% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Fab fragment of monoclonal antibody | protein | 219 | 5% helix, 51% strand | — |
| H | Fab fragment of monoclonal antibody | protein | 220 | 4% helix, 50% strand | — |
| E | Antigenic nonapeptide | protein | 9 | 44% helix, 0% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 414 | 0.56 | 0.73 | 52 | empty |
| 2 | 111 | 0.39 | 0.75 | 24 | empty |
| 3 | 95 | 0.35 | 0.74 | 17 | empty |
Interfaces
3 interfaces between chains.
- L–H · 1993 Ų buried · 27 hydrogen bonds · protein-protein
- H–E · 340 Ų buried · 2 hydrogen bonds · protein-protein
- L–E · 243 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 1F90 · Fab fragment of monoclonal antibody (lnkb-2) against human interleukin-2 in complex with… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1F90 · PDBe 1F90
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