MolNFT v1 · #63199 · protein
Crystal structure of merb mutant C160S, the organomercurial lyase involved in a bacterial mercury resistance system
3F2G · Alkylmercury lyase: “Crystal structure of merb mutant C160S, the organomercurial lyase involved in a bacterial mercury resistance…”. X-ray diffraction, 5 pockets (best druggability 0.82). MolNFT v1 #63199 on GenesisL1: 3D structure…
- PDB
- 3F2G
- Type
- protein
- Length
- 413 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alkylmercury lyase
- EC
- 4.99.1.2
- UniProt
- P77072
- Pockets
- 5 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alkylmercury lyase (EC 4.99.1.2) | protein | 205 | 42% helix, 20% strand | P77072 |
| B | Alkylmercury lyase (EC 4.99.1.2) | protein | 208 | 41% helix, 21% strand | P77072 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 286 | 0.82 | 0.93 | 33 | empty |
| 2 | 277 | 0.82 | 0.93 | 35 | empty |
| 3 | 943 | 0.82 | 0.83 | 83 | empty |
| 4 | 128 | 0.44 | 0.77 | 19 | empty |
| 5 | 112 | 0.43 | 0.77 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 988 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 3F2G · Crystal structure of MerB mutant C160S, the Organomercurial Lyase involved in a bacterial… · the same entry in another collection · chain A against A, TM-score 1.00
- P77072 · AlphaFold monomer V2.0 prediction for alkylmercury lyase (P77072) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P77072
- Elsewhere: RCSB PDB 3F2G · PDBe 3F2G · UniProt P77072
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.