MolNFT v1 · #63171 · protein
Human escrt-0 core complex
3F1I · Hepatocyte growth factor-regulated tyrosine kinase substrate: “Human escrt-0 core complex”. X-ray diffraction, 1 pocket (best druggability 0.49). MolNFT v1 #63171 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3F1I
- Type
- protein
- Length
- 199 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hepatocyte growth factor-regulated tyrosine kinase substrate; Signal transducing adapter…
- UniProt
- O14964, Q92783
- Pockets
- 1 · best druggability 0.49
Structure
x-ray diffraction · 3 distinct chains · 87% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Hepatocyte growth factor-regulated tyrosine kinase substrate | protein | 98 | 93% helix, 0% strand | O14964 |
| S | Signal transducing adapter molecule 1 | protein | 77 | 79% helix, 0% strand | Q92783 |
| C | Signal transducing adapter molecule 1 | protein | 24 | 92% helix, 0% strand | Q92783 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 180 | 0.49 | 0.77 | 20 | empty |
Interfaces
3 interfaces between chains.
- H–S · 1892 Ų buried · 13 hydrogen bonds · protein-protein
- S–C · 643 Ų buried · 8 hydrogen bonds · protein-protein
- H–C · 70 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3F1I · Human ESCRT-0 Core Complex · the same entry in another collection · chain H against H, TM-score 1.00
- Q92783 · AlphaFold monomer V2.0 prediction for signal transducing adapter molecule 1 (Q92783) · a predicted model of the same protein · chain S against A, TM-score 0.92
- O14964 · AlphaFold monomer V2.0 prediction for hepatocyte growth factor- regulated tyrosine kinase… · a predicted model of the same protein · chain H against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14964
- Every structure of UniProt Q92783
- Elsewhere: RCSB PDB 3F1I · PDBe 3F1I · UniProt O14964 · UniProt Q92783
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