MolNFT v1 · #63082 · protein
Crystal structure of MJ5 Fab, a germline antibody variant of anti-human cytomegalovirus antibody 8F9
3EYQ · M2J5 Fab: “Crystal structure of MJ5 Fab, a germline antibody variant of anti-human cytomegalovirus antibody 8F9”. X-ray diffraction, 3 pockets (best druggability 0.52). MolNFT v1 #63082 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3EYQ
- Type
- protein
- Length
- 420 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- M2J5 Fab; 8F9 Fab
- Pockets
- 3 · best druggability 0.52
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | M2J5 Fab | protein | 212 | 4% helix, 48% strand | — |
| D | 8F9 Fab | protein | 208 | 9% helix, 52% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 334 | 0.52 | 0.73 | 50 | empty |
| 2 | 116 | 0.37 | 0.74 | 20 | empty |
| 3 | 56 | 0.27 | 0.74 | 14 | empty |
Interfaces
1 interface between chains.
- C–D · 1614 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 3EYQ · Crystal structure of MJ5 Fab, a germline antibody variant of anti-human cytomegalovirus… · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3EYQ · PDBe 3EYQ
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