MolNFT v1 · #62994 · protein
The 1:2 complex between a nterminal elongated prolactin and the extra cellular domain of the rat prolactin receptor
3EW3: “The 1:2 complex between a nterminal elongated prolactin and the extra cellular domain of the rat prolactin…”. X-ray diffraction, 8 pockets (best druggability 0.75). MolNFT v1 #62994 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3EW3
- Type
- protein
- Length
- 569 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Prolactin; Prolactin receptor
- UniProt
- P01236, P05710
- Pockets
- 8 · best druggability 0.75
Structure
x-ray diffraction · 3 distinct chains · 21% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Prolactin | protein | 185 | 62% helix, 0% strand | P01236 |
| B | Prolactin receptor | protein | 203 | 1% helix, 42% strand | P05710 |
| C | Prolactin receptor | protein | 181 | 2% helix, 43% strand | P05710 |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1081 | 0.75 | 0.78 | 65 | empty |
| 2 | 82 | 0.63 | 0.90 | 16 | empty |
| 3 | 217 | 0.51 | 0.76 | 30 | empty |
| 4 | 206 | 0.46 | 0.74 | 27 | empty |
| 5 | 103 | 0.43 | 0.78 | 21 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1206 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 816 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 565 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 3EW3 · the 1:2 complex between a Nterminal elongated prolactin and the extra cellular domain of… · the same entry in another collection · chain A against A, TM-score 1.00
- P05710 · AlphaFold monomer V2.0 prediction for prolactin receptor (P05710) · a predicted model of the same protein · chain B against A, TM-score 0.97
- P01236 · AlphaFold monomer V2.0 prediction for prolactin (P01236) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01236
- Every structure of UniProt P05710
- Elsewhere: RCSB PDB 3EW3 · PDBe 3EW3 · UniProt P01236 · UniProt P05710
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.